HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors
نویسندگان
چکیده
منابع مشابه
HCN4 dynamically marks the first heart field and conduction system precursors.
RATIONALE To date, there has been no specific marker of the first heart field to facilitate understanding of contributions of the first heart field to cardiac lineages. Cardiac arrhythmia is a leading cause of death, often resulting from abnormalities in the cardiac conduction system (CCS). Understanding origins and identifying markers of CCS lineages are essential steps toward modeling disease...
متن کاملExtended atrial conduction system characterised by the expression of the HCN4 channel and connexin45.
OBJECTIVE In the heart, there are multiple supraventricular pacemakers involved in normal pacemaking as well as arrhythmias and the objective was to determine the distribution of HCN4 (major isoform underlying the pacemaker current, I(f)) in the atria. METHODS In the atria of the rat, the localisation of HCN4 and connexins was determined using immunohistochemistry, and electrical activity was...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.301588